Other issues

Several other problems may also occur in Lesch-Nyhan disease. One of these is recurrent vomiting. This is sometimes severe enough to impair nutrition and growth. If it is severe, a feeding tube may have to be inserted into the stomach.

Another problem is anemia with very large red cells in the blood. This problem is usually caused by dietary deficiency of vitamin B12 or folic acid, and sometimes by other problems. However, patients with Lesch-Nyhan disease do not usually have such deficiencies, and supplements do not correct the anemia. Fortunately, it does not usually cause significant disability, so it does not need to be treated.